Modifications of lung clearance mechanisms by acute influenza A infection
Four volunteers with naturally acquired, culture-proved influenza A infection inhaled a radiolabeled aerosol to permit investigation of lung mucociliary clearance mechanisms during and after symptomatic illness. Mucus transport in the trachea was undetectable when monitored with an external multidetector probe within 48 hours of the onset of the illness, but was found at a normal velocity by 1 week in three of the four subjects. In two volunteers who coughed 23 to 48 times during the 4.5-hour observation period, whole lung clearance was as fast within the first 48 hours of illness as during health 3 months later in spite of the absence of measurable tracheal mucus transport. Conversely, in spite of the return 1 week later of mucus transport at velocities expected in the trachea, whole lung clearance for the 4.5-hour period was slowed in two volunteers who coughed less than once an hour. The data offer evidence that cough is important in maintaining lung clearance for at least several days after symptomatic influenza A infection when other mechanisms that depend on ciliary function are severely deficient.
- Research Organization:
- Univ. of Illinois College of Medicine, Chicago
- OSTI ID:
- 6043827
- Journal Information:
- J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 4; ISSN JLCMA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DISEASES
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
INFECTIOUS DISEASES
INFLUENZA
INFLUENZA VIRUSES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
PARASITES
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACHEA
VIRAL DISEASES
VIRUSES
YEARS LIVING RADIOISOTOPES