Inhaled histamine increases human lung mucociliary transport

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5492656

Mussatto, D J; Garrard, C S; Trumbull, J J; Bowers, M W; Sanders, C J; Yeates, D B; Lourenco, R V

Histamine, a mediator of airways constriction, alters ciliary beat frequency, bronchial mucus production, and epithelial ion transport; and in dogs, increases mucociliary transport. To evaluate the effect of inhaled histamine on human tracheobronchial mucociliary clearance, the authors measured lung mucociliary clearance (LMC) and tracheal mucociliary transport rate (TMTR) in 5 healthy, nonsmoking subjects in a randomized, double-blind, cross-over study. The concentration of inhaled histamine which produced a 20% fall in FEV/sub 1/ was established for each subject. On a separate day the subjects inhaled a 9 ..mu..m MMAD /sup 99m/Tc-Fe/sub 2/O/sub 3/ aerosol. LMC and TMTR were then measured for 2.5h using a gamma camera and a tracheal multidetector probe. Simultaneously, the subjects were challenged every 26 +/- 4 min with either PBS or histamine in PBS. The Fe/sub 2/O/sub 3/ retained after 24h for histamine (14.4 +/- 7.6%) and PBS studies (13.1 +/- 8.6%) indicated no difference in deposition of Fe/sub 2/O/sub 3/ (ANOVA). Fe/sub 2/O/sub 3/ clearance at 30 min was increased in the histamine studies (61 +/- 21% compared to the PBS studies (44 +/- 29%; p < 0.02, ANOVA)). TMTR was also increased with histamine (7.6 +/- 3.4 mm/min) compared to PBS (4.6 +/- 1.7 mm/min; p < 0.001, ANOVA). Results indicate an acute stimulatory effect of inhaled histamine on mucous transport in humans.

• Research Organization: Univ. of Illinois, Chicago
• OSTI ID: 5492656
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CLEARANCE
EXCRETION
HETEROCYCLIC COMPOUNDS
HISTAMINE
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
IRON OXIDES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRACHEA
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES