Mucus rheology and mucociliary clearance: normal physiologic state

Journal Article · Sat Dec 31 23:00:00 EST 1977 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5290013

Giordano, A M; Holsclaw, D; Litt, M

Tracheal mucociliary clearance studies, mucus collections, and rheologic studies were performed on a weekly basis in 7 adult purebred beagles in an attempt to correlate clearance rate with rheology of mucus. Clearance rates were determined by a percutaneous transtracheal, radioisotope injection technique. Mucus was collected from dogs equipped with a tracheal pouch, and rheologic determinations were performed on a dynamic microrheometer. Individual analysis of data for each dog failed to reveal any significant relationship between clearance rate and any parameter of elasticity or viscosity. However, when data from all 7 dogs were pooled, covering a much wider range of the measured variables, it was seen that as the elastic modulus increased, the rate of clearance decreased. The mucociliary clearance rate was halved by an approximate ten-fold increase in elastic modulus of mucus.

• Research Organization: Hahnemann Medical College and Hospital, Philadelphia, PA
• OSTI ID: 5290013
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 118; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DYNAMIC FUNCTION STUDIES
ELASTICITY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MECHANICAL PROPERTIES
MUCOUS MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
RHEOLOGY
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACHEA
VERTEBRATES
VISCOSITY
YEARS LIVING RADIOISOTOPES