Effects of various drugs on canine tracheal mucociliary transport

Journal Article · Sat Jul 01 00:00:00 EDT 1978 · Ann. Otol., Rhinol., Laryngol.; (United States)

DOI:https://doi.org/10.1177/000348947808700405· OSTI ID:5299449

Giordano, A; Holsclaw, D; Litt, M

A study of the effects of dehydration, atropine, terbutaline and N-acetylcysteine on canine tracheobronchial mucus is presented. Mucociliary clearance rates, mucus secretion volumes and mucus rheologic properties were studied. Clearance rates were studied by a radioisotope technique mucus collected by a canine Tracheal pouch method and rheologic studies performed on a microrheometer. Clearance rate was unaffected by dehydration and terbutaline, increased by N-acetylcysteine and decreased by atropine. Secretion volume was increased by terbutaline while dehydration and atropine were without effect. Rheologic factors were increased by dehydration and atropine while terbutaline was without an effect. The effects of N-acetylcysteine on secretion volume and rheologic properties could not be studied because of the nature of the techniques employed.

• OSTI ID: 5299449
• Journal Information: Ann. Otol., Rhinol., Laryngol.; (United States), Journal Name: Ann. Otol., Rhinol., Laryngol.; (United States) Vol. 87:4; ISSN AORHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALOIDS
ANIMALS
ATROPINE
BEAGLES
BIOLOGICAL EFFECTS
BRONCHI
CLEARANCE
DEHYDRATION
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
ISOTOPE APPLICATIONS
MAMMALS
MUCOUS MEMBRANES
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
PHARMACOLOGY
RESPIRATORY SYSTEM
RHEOLOGY
SECRETION
TECHNETIUM ISOTOPES
TRACHEA
VERTEBRATES