Increased C1q binding immune complexes in Felty's syndrome: comparison with uncomplicated rheumatoid arthritis
Journal Article
·
· Arthritis Rheum.; (United States)
Sera from patients with Felty's syndrome (FS) and rheumatoid arthritis (RA) were examined for the presence of circulating immune complexes (IC) by using the 125I-C1q binding and monoclonal rheumatoid factor (mRF) techniques. Of 15 patients with FS, 9 (60%) had high 125I-C1q binding as compared to 3 of 26 RA patients (12%). The average C1q binding was significantly higher in the FS patients than in the RA patients without FS. C1q binding in both FS and RA patients was significantly higher than a group of 90 normal controls. In addition, serum C4 levels were significantly lower in the FS patients than in the RA patients. In contrast to these findings, IC levels in FS and RA patients were very similar when measured by the mRF technique. These studies indicate that FS patients have higher levels of complement-fixing IC in their sera than RA patients without FS. These findings raise the possibility that the complement-fixing IC found in these patients may play a role in the pathogenesis of neutropenia of FS.
- Research Organization:
- Univ. of Texas Health Science Center, Dallas
- OSTI ID:
- 6043032
- Journal Information:
- Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 22:7; ISSN ARHEA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
·
Sat May 01 00:00:00 EDT 1982
· J. Lab. Clin. Med.; (United States)
·
OSTI ID:6780946
Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioimmunoassay with monoclonal rheumatoid factor. [/sup 125/I tracer technique]
Conference
·
Fri Aug 01 00:00:00 EDT 1975
· J. Clin. Invest.; (United States)
·
OSTI ID:7352734
Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay
Journal Article
·
Fri Jul 01 00:00:00 EDT 1983
· Arthritis Rheum.; (United States)
·
OSTI ID:5551102
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATHOGENESIS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RHEUMATIC DISEASES
SKELETAL DISEASES
TRACER TECHNIQUES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FEMALES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATHOGENESIS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RHEUMATIC DISEASES
SKELETAL DISEASES
TRACER TECHNIQUES