Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay
Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.
- Research Organization:
- Veterans Administration Medical Center, Memphis, Tennessee
- OSTI ID:
- 5551102
- Journal Information:
- Arthritis Rheum.; (United States), Vol. 26:7
- Country of Publication:
- United States
- Language:
- English
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COLLAGEN
RADIOIMMUNOASSAY
ANTIBODIES
IODINE 125
RHEUMATIC DISEASES
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOISOTOPES
SCLEROPROTEINS
SKELETAL DISEASES
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics