Radiation response of the cells of a human malignant melanoma xenograft. Effect of hypoxic cell radiosensitizers
Journal Article
·
· Radiat. Res.; (United States)
The radiation response of the cells of E. E. malignant melanoma irradiated in suspension in vitro and as solid tumors in the athymic mutant nude mouse was studied. The dose-response curves for cells irradiated in vitro under aerobic and extremely hypoxic conditions indicated that the cells have a considerable capacity for accumulation of sublethal damage. The terminal slope of the dose-response curves for tumors irradiated in air-breathing or dead mice was not significantly different from that measured for extremely hypoxic cells irradiated in vitro. The shoulder of the dose-response curve for cells irradiated as tumors in dead mice (n = 42/sub -21//sup +43/) was at least as large as that for cells irradiated in suspension under extremely hypoxic conditions. By assuming that acute and chronically hypoxic cells showed the same response to radiation, the fraction of hypoxic cells in the tumors was determined to be 5 to 10%.
- Research Organization:
- Norsk Hydro's Inst. for Cancer Research, Oslo, Norway
- OSTI ID:
- 6042400
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 87:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COMPARATIVE EVALUATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HISTOLOGY
IMIDAZOLES
IN VITRO
IONIZING RADIATIONS
MAMMALS
MELANOMAS
MICE
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COMPARATIVE EVALUATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HISTOLOGY
IMIDAZOLES
IN VITRO
IONIZING RADIATIONS
MAMMALS
MELANOMAS
MICE
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
TUMOR CELLS
VERTEBRATES
X RADIATION