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Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contact

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576103· OSTI ID:5392004
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Contact effect (CE) and hypoxia have been studied in human tumor cell lines transplanted in athymic nude mice. Four cell lines--one melanoma (Bell) and three colorectal adenocarcinomas (HT29, HRT18, and HCT8)--were studied. Cell survival was determined with an in vivo to in vitro colony-forming assay. Survival curves were obtained under three different conditions: (1) tumor cells irradiated in air-breathing mice, (2) tumor cells irradiated in animals asphyxiated for 10 min, and (3) tumor cells plated and irradiated either immediately or 5 hr later. For all cell lines, radiosensitivity appeared to be lower when cells were irradiated in vivo than when they were irradiated in vitro. Only in the case of the HCT8 tumor did the relative in vivo radioresistance seem to be linked to hypoxia; in the other cell lines, hypoxia alone could not account for the lower in vivo radiosensitivity. Our results suggest that a CE plays an important role in the response of human tumor xenografts to irradiation.
Research Organization:
Laboratoire de Radiobiologie Cellulaire (Unite INSERM 247), Institut Gustave-Roussy, Villejuif, France
OSTI ID:
5392004
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 95:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BODY
CELL CULTURES
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MAMMALS
MAN
MEDICINE
MELANOMAS
MICE
NEOPLASMS
ORGANS
PRIMATES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SURGERY
SURVIVAL CURVES
THYMECTOMY
TRANSPLANTS
VERTEBRATES