Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Radiosensitivity of lymph node metastases versus initial subcutaneous tumors in nude mice. [EMT6 tumor cells;. gamma. rays]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575044· OSTI ID:6254496
; ; ;
The in vivo and in vitro radiosensitivity of EMT6 tumor cells growing subcutaneously and metastasizing to the regional lymph nodes has been studied in congenitally athymic nude mice. The fraction of hypoxic cells was determined using an in vitro colony method to assay cell survival after irradiation of both air-breathing and nitrogen-asphyxiated animals. In air-breathing animals, lymph node metastases contained a significantly higher fraction of hypoxic cells than subcutaneous tumors of the same size (61 and 36% respectively). Survival curves did not differ under hypoxic conditions (nitrogen-asphyxiated animals). Likewise, survival curves of cells extracted from tumors at both sites and irradiated in vitro were identical.
Research Organization:
Institut de Radiobiologie Clinique, Villejuif, France
OSTI ID:
6254496
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:2; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Effect of size of lymph node metastases on the radiation response: influence of misonidazole
Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Radiat. Res.; (United States) · OSTI ID:7057607
Effects of sodium pentobarbital on the radiation response of EMT6 cells in vitro and EMT6 tumors in vivo
Journal Article · Thu Jan 31 23:00:00 EST 1980 · Radiat. Res.; (United States) · OSTI ID:5211213
Radiosensitivity of four human tumor xenografts. Influence of hypoxia and cell-cell contact
Journal Article · Thu Sep 01 00:00:00 EDT 1983 · Radiat. Res.; (United States) · OSTI ID:5392004

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560151 -- Radiation Effects on Animals-- Man
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANOXIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
GAMMA RADIATION
GRAPHS
IN VITRO
IN VIVO
INFORMATION
INJECTION
INTAKE
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
LEGS
LIMBS
LOCAL IRRADIATION
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
METASTASES
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SUBCUTANEOUS INJECTION
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES