Morphologic alterations in canine marrow of long-term survivors after 1200 R whole-body x-irradiation and autologous blood leukocyte engraftment
The marrow matrix of total-body x-irradiated dogs (1200 R midline dose) was able to support effective hemopoiesis for several hundred days if the animals were transfused with their own mononclear leukocytes collected from the blood prior to irradiation and preserved at ultralow temperatures. However, a lesion developed in the marrow, consisting of a fibrosis originating in conjunction with or from the endosteum. The fibrotic tissue substantially reduced the available marrow space in dogs with advanced lesions. The number of autologous, cryopreserved mononuclear leukocytes transfused ranged from 0.32 x 10(9) to 1.63 x 10(9)/kg body weight. The observation period extended to a maximum of 898 days after irradiation.
- Research Organization:
- Univ. of Ulm, Germany
- OSTI ID:
- 6041757
- Journal Information:
- Am. J. Pathol.; (United States), Vol. 95:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD FORMATION
BIOLOGICAL RADIATION EFFECTS
DOGS
WHOLE-BODY IRRADIATION
BONE MARROW
DELAYED RADIATION EFFECTS
MORPHOLOGICAL CHANGES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560114 - Radiation Effects on Biochemicals- In Animals- (-1987)