Morphologic alterations in canine marrow of long-term survivors after 1200 R whole-body x-irradiation and autologous blood leukocyte engraftment

Journal Article · Tue May 01 04:00:00 EDT 1979 · Am. J. Pathol.; (United States)

OSTI ID:6041757

Calvo, W; Fliedner, T M; Steinbach, I; Alcober, V; Nothdurft, W; Fache, I

The marrow matrix of total-body x-irradiated dogs (1200 R midline dose) was able to support effective hemopoiesis for several hundred days if the animals were transfused with their own mononclear leukocytes collected from the blood prior to irradiation and preserved at ultralow temperatures. However, a lesion developed in the marrow, consisting of a fibrosis originating in conjunction with or from the endosteum. The fibrotic tissue substantially reduced the available marrow space in dogs with advanced lesions. The number of autologous, cryopreserved mononuclear leukocytes transfused ranged from 0.32 x 10(9) to 1.63 x 10(9)/kg body weight. The observation period extended to a maximum of 898 days after irradiation.

• Research Organization: Univ. of Ulm, Germany
• OSTI ID: 6041757
• Journal Information: Am. J. Pathol.; (United States), Journal Name: Am. J. Pathol.; (United States) Vol. 95:2; ISSN AJPAA
• Country of Publication: United States
• Language: English

Related Subjects

560114 -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FORMATION
BODY
BONE MARROW
DELAYED RADIATION EFFECTS
DOGS
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
RADIATION EFFECTS
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION