Enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats

Journal Article · Sat Jan 01 04:00:00 EST 1972 · Lipids; (United States)

DOI:https://doi.org/10.1007/BF02533017· OSTI ID:6036219

Chow, C K; Tappel, A L

Rats were fed a vitamin E-deficient diet containing 1 to 1500 mg dl-..cap alpha..-tocopherol acetate per kilogram and then exposed to 0.7 or 0.8 ppM O/sub 3/ for 5 or 7 days. Lung homogenates were analyzed for enzyme activities. O/sub 3/ elevated thiobarbituric acid (TBA) test dreactants, primarily malonaldehyde produced by lipid peroxidation, as well as activities of GSH peroxidase, G-6-P dehydrogenase, and GSH reductase. The first three effects were partially inhibited by increasing dietary tocopherol (log basis) but the last was not affected. Compensation mechanism (homeostasis) to lipid peroxidation is: (a) increase in GSH peroxidase (increased lipid peroxide catabolism), (b) increase in GSH reductase (provides more GSH for (a)), and (c) increase in G-6-P dehydrogenase (provides more Nadph.

• OSTI ID: 6036219
• Journal Information: Lipids; (United States), Journal Name: Lipids; (United States) Vol. 7; ISSN LPDSA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
AZINES
BARBITURATES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHEMISTRY
DICARBOXYLIC ACIDS
DRUGS
ENZYMES
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
HOMEOSTASIS
HYPNOTICS AND SEDATIVES
LIPIDS
MALONIC ACID
MAMMALS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXYGEN COMPOUNDS
OZONE
PEROXIDES
PYRIMIDINES
RATS
RESPIRATORY TRACT CELLS
RODENTS
SACCHARIDES
VERTEBRATES
VITAMIN E
VITAMINS