Pulmonary metabolism of foreign compounds: Its role in metabolic activation
Journal Article
·
· Environmental Health Perspectives; (USA)
- Univ. of London (England)
The lung has the potential of metabolizing many foreign chemicals to a vast array of metabolites with different pharmacological and toxicological properties. Because many chemicals require metabolic activation in order to exert their toxicity, the cellular distribution of the drug-metabolizing enzymes in a heterogeneous tissue, such as the lung, and the balance of metabolic activation and deactivation pathways in any particular cell are key factors in determining the cellular specificity of many pulmonary toxins. Environmental factors such as air pollution, cigarette smoking, and diet markedly affect the pulmonary metabolism of some chemicals and, thereby, possibly affect their toxicity.
- OSTI ID:
- 6034556
- Journal Information:
- Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 85; ISSN 0091-6765; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
AROMATICS
BENZOPYRENE
BIOLOGICAL PATHWAYS
BODY
CHEMICAL REACTIONS
CONDENSED AROMATICS
ENZYME ACTIVITY
ENZYMES
HYDROCARBONS
LUNGS
METABOLIC ACTIVATION
METABOLITES
METHYL TRANSFERASES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHARMACOLOGY
POLYCYCLIC AROMATIC HYDROCARBONS
RESPIRATORY SYSTEM
TRANSFERASES
XENOBIOTICS
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATION
AROMATICS
BENZOPYRENE
BIOLOGICAL PATHWAYS
BODY
CHEMICAL REACTIONS
CONDENSED AROMATICS
ENZYME ACTIVITY
ENZYMES
HYDROCARBONS
LUNGS
METABOLIC ACTIVATION
METABOLITES
METHYL TRANSFERASES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHARMACOLOGY
POLYCYCLIC AROMATIC HYDROCARBONS
RESPIRATORY SYSTEM
TRANSFERASES
XENOBIOTICS