Metabolism of benzo(a)pyrene in cultured human bronchus
Technical Report
·
OSTI ID:5513463
Lung cancer is a major cause of cancer deaths in many countries. Based on clinical, experimental, epidemiologic and autopsy data, cigarette smoking has been identified as the major risk factor in the development of lung cancer. The majority of lung cancers in man are bronchiogenic carcinomas which are thought to arise from a metaplastic squamous differentiation of the large bronchi. Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (PB), found in cigarette smoke and environmental pollutants, were associated with lung cancer in man. Since most chemical carcinogens have to be metabolically activated in the body before exerting their carcinogenicity, it is important to study the metabolic fate of benzo(a)pyrene in the human bronchus. Recent developments in the maintenance and growth of viable human epithelial tissues and cells in vitro have made possible the study of chemical carcinogenesis directly in human tissue.
- Research Organization:
- Medical Coll. of Ohio, Toledo (USA)
- OSTI ID:
- 5513463
- Report Number(s):
- N-8326405; CONF-8111192-
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AROMATICS
BENZOPYRENE
BODY
BRONCHI
CARCINOGENESIS
CARCINOGENS
COLLOIDS
CONDENSED AROMATICS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
HISTOLOGY
HYDROCARBONS
METABOLIC ACTIVATION
METABOLISM
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
TABLES
TISSUES
TOBACCO PRODUCTS
TOBACCO SMOKES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AROMATICS
BENZOPYRENE
BODY
BRONCHI
CARCINOGENESIS
CARCINOGENS
COLLOIDS
CONDENSED AROMATICS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
HISTOLOGY
HYDROCARBONS
METABOLIC ACTIVATION
METABOLISM
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
TABLES
TISSUES
TOBACCO PRODUCTS
TOBACCO SMOKES