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Increased production of plasminogen activator inhibitor in vitro by pleural leukocytes from rats intratracheally instilled with crocidolite asbestos

Journal Article · · Environmental Research; (United States)
OSTI ID:6024398
; ;  [1];  [2]
  1. Inst. of Occupational Medicine, Edinburgh (Scotland)
  2. Univ. of Edinburgh (Scotland)
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The authors have previously reported that normal pleural leukocytes secrete a urokinase-type plasminogen activator inhibitor (PAI) in culture. In view of the pathogenic effects of asbestos on the pleura, in particular pleural fibrosis, they have extended these observation to crocidolite asbestos-exposed rats. Pleural leukocytes from rats exposed to crocidolite asbestos were found to secrete more PAI in culture than controls. The activity of PAI in pleural leukocyte-conditioned medium increased in a dose-dependent manner in relation to the quantity of asbestos injected into the lung. However, with increasing time post asbestos instillation, there was no significant change in the secretion of PAI by pleural leukocytes in culture compared with earlier time points of crocidolite-exposed rats. Plasminogen activator was not detectable in the conditioned medium at any time point. The data derived from this study may help to elucidate the pathogenesis of some pleural disorders caused by exposure to fibrous dusts in the lungs.
OSTI ID:
6024398
Journal Information:
Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 55:2; ISSN ENVRA; ISSN 0013-9351
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY FLUIDS
COAGULANTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYME INHIBITORS
FIBERS
FIBRINOLYTIC AGENTS
HEMATOLOGIC AGENTS
IN VITRO
INTRATRACHEAL ADMINISTRATION
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANES
ORGANIC COMPOUNDS
PATHOGENESIS
PLASMINOGEN
PLEURA
PROTEINS
RATS
RESPIRATORY SYSTEM DISEASES
RODENTS
SEROUS MEMBRANES
TOXICITY
VERTEBRATES