Functional and biochemical effects on rat lung following instillation of crocidolite and chrysotile asbestos

Journal Article · Fri Jan 01 04:00:00 EST 1988 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531139· OSTI ID:7090311

Hirano, S; Ono, M; Aimoto, A

Groups of rats received a single intratracheal instillation of saline (control), 1.6 mg crocidolite, and 1.6 mg chrysotile. At 1, 3, 6, 9, and 12 mo after instillation, respiratory functional tests were performed and the lungs were biochemically analyzed. Throughout 12 mo, obstructive small-airway abnormalities with air trapping were observed in the asbestos-treated rats. The degree of airway obstruction and air trapping was higher in the chrysotile-treated group than in the crocidolite-treated group. Lung weight increased significantly in both asbestos-treated groups. Collagen and elastin content of unit lung weight significantly increased in the chrysotile-treated group compared with the control and crocidolite-treated group throughout the experimental period up to 12 mo. However, the collagen and elastin content of unit lung weight in the crocidolite-treated group was not as different from the control group. These results indicate that chrysotile is more fibrogenic than crocidolite, as has been suggested in histopathological studies.

• Research Organization: National Institute for Environmental Studies, Ibaraki (Japan)
• OSTI ID: 7090311
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 24:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BIOCHEMICAL REACTION KINETICS
BODY
INTRATRACHEAL ADMINISTRATION
KINETICS
LUNGS
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
RATS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES