Effects of cigarette smoking on metabolic events in the lung

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8772283· OSTI ID:6016381

Kitamura, S

Nicotine and cigarette smoke extract show acute physiological effects: increasing tracheal pressure (P/sub TR/), pulmonary artery pressure (P/sub PA/), systemic blood pressure (P/sub SYST/), and left atrium pressure (P/sub LA/); and decreasing cardiac output (Q/sub AORTA/) and blood flow to the left lower lobe (Q/sub LLL/). In addition, cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEV/sub 1.0/ in healthy subjects. It has also been demonstrated that cigarette smoking caused temporary slowing of mucociliary clearance in the lung and that cigarette smoke increases the activity of aryl hydrocarbon hydroxylase which metabolizes benzo(..cap alpha..)pyrene. The authors demonstrated that serum angiotensin I converting enzyme (ACE) activity showed a significant increase immediately after smoking and returned to the control level 20 min after smoking. They also demonstrated that plasma histamine levels showed a marked decrease after smoking. Furthermore, the effects of cigarette smoke and related substances on prostaglandin, thromboxane, testosterone, cyclic nucleotides metabolism, and protein synthesis were also investigated.

• Research Organization: Jichi Medical School, Tochigi, Japan
• OSTI ID: 6016381
• Journal Information: Environ. Health Perspect.; (United States), Vol. 72
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
METABOLISM
LUNGS
PHYSIOLOGY
TOBACCO SMOKES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
ENZYME ACTIVITY
HYDROXYLASES
LUNG CLEARANCE
NICOTINE
NUCLEOTIDES
PROSTAGLANDINS
SEROTONIN
TESTOSTERONE
AEROSOLS
ALKALOIDS
AMINES
ANDROGENS
ANDROSTANES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
BODY
CLEARANCE
COLLOIDS
CONDENSED AROMATICS
DISPERSIONS
DRUGS
ENZYMES
EXCRETION
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROCARBONS
HYDROXY COMPOUNDS
INDOLES
KETONES
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PYRIDINES
PYRROLES
PYRROLIDINES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
TRYPTAMINES
560300* - Chemicals Metabolism & Toxicology