Neutropenia fails to prevent the acute phase stimulation of fibrinogen synthesis
This study evaluates the role of neutrophil granulocytes in mediating acute phase stimulation of fibrinogen synthesis. Turpentine was administered to neutropenic and non-neutropenic rats and fibrinogen synthetic rates measured in an isolated liver perfusion system. Using the (/sup 14/C) carbonate technique for the measurement of the absolute synthetic rates of liver produced plasma proteins it was observed that the rates of fibrinogen synthesis of the neutropenic and non-neutropenic rats were significantly greater (p less than 0.01) than those of normal control animals, but were not significantly different from each other. These results suggest that the neutrophil granulocyte may not be of major importance in mediating acute phase stimulation of fibrinogen synthesis.
- Research Organization:
- Department of Haematology, University of Cape Town Medical School, South Africa
- OSTI ID:
- 5999121
- Journal Information:
- Thromb. Res.; (United States), Vol. 28:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FIBRINOGEN
BIOSYNTHESIS
NEUTROPHILS
BIOLOGICAL FUNCTIONS
TURPENTINE
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
LEUKOPENIA
LIVER
PATHOLOGY
RATS
TRACER TECHNIQUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY
BODY FLUIDS
COAGULANTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FUNCTIONS
GLANDS
GLOBULINS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HEMOSTATICS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
ORGANS
PROTEINS
RODENTS
SOLVENTS
SYNTHESIS
TERPENES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)