/sup 195m/Au, an ultra-short-lived generator-produced radionuclide: clinical application in sequential first pass ventriculography
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5997634
/sup 195m/Au (Au-195m) has a half-life of 30.5 sec and can be produced at the bedside from the parent /sup 195m/Hg (T 1/2 . 41.6 hr). The generator produced sterile pyrogen-free /sup 195m/Au with mercury breakthrough of 0.75 +/- 0.09 (s.e.m.) muCi per mCi of /sup 195m/Au. Approximately 20 to 25 mCi of /sup 195m/Au was produced per elution from a generator containing 155 mCi of /sup 195m/Hg. We compared first-pass resting /sup 99m/Tc angiograms with /sup 195m/Au angiograms in 28 patients. The correlation coefficient between the two studies was 0.92 over an ejection-fraction range from 0.22 to 0.83. In addition, we tested the reproducibility of /sup 195m/Au first-pass angiograms by performing two studies 3 min apart. In 25 patients with ejection fractions ranging from 0.20 to 0.78, the correlation coefficient between such pairs was 0.93. The nuclide is reliably and reproducibly produced, and its short half-life allows the performance of background-free sequential first-transit studies with unusually low radiation exposure to the patient.
- Research Organization:
- Harbor-UCLA Medical Center, Torrance, California
- OSTI ID:
- 5997634
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:2; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BLOOD CIRCULATION
BODY
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
GOLD 195
GOLD ISOTOPES
HEART
HEAVY NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
USES
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BLOOD CIRCULATION
BODY
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
GOLD 195
GOLD ISOTOPES
HEART
HEAVY NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
USES