Gold-195m, a new generator-produced short-lived radionuclide for sequential assessment of ventricular performance by first pass radionuclide angiocardiography. [Dogs]
The feasibility of performing rapid sequential first pass radionuclide angiocardiography using a new short-lived radiotracer, gold-195m (/sup 195//sup m/Au) half-life 30.5 seconds) was evaluated. This radionuclide emits a 262 keV gamma ray and is the daughter of mercury-195 (/sup 195//sup m/Hg) (half-life 41.6 hours). The prototype table top /sup 195//sup m/Hg//sup 195//sup m/Au generator produced 20 to 25 mCi of /sup 195//sup m/Au in 2 ml of eluate (yield of 40 percent). Four dogs each had 15 to 20 sequential first pass studies performed with /sup 195//sup m/Hg at 3 to 10 minute intervals using a computerized multicrystal gamma camera. During the left ventricular phase, 160,000 to 190,000 counts/s were acquired. The end-diastolic left ventricular region of interest contained 3000 to 6000 counts (background- and decay-corrected). Multiple reproducible values for left ventricular ejection fraction were obtained during stable conditions. During infusion of isoproterenol, rapid increase of left ventricular ejection fraction was demonstrated. Excellent agreement was observed between studies performed with technetium-99m diethylenetriaminepentaacetic acid (/sup 99//sup m/Tc-DTPA) and /sup 195//sup m/Au. This new short-lived radiotracer makes possible rapid sequential assessments of ventricular function at greatly reduced patient exposure to radiation.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- DOE Contract Number:
- AC02-78EV04625
- OSTI ID:
- 5176370
- Journal Information:
- Am. J. Cardiol.; (United States), Vol. 50
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
GOLD 195
SCINTISCANNING
HEART
DYNAMIC FUNCTION STUDIES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
DOGS
ISOMERIC NUCLEI
RADIATION DOSES
RADIOCARDIOGRAPHY
RADIOISOTOPE GENERATORS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOGRAPHY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GOLD ISOTOPES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials