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Gold-195m, an ultra-short-lived generator-produced radionuclide: clinical application in sequential first pass ventriculography

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5855948
; ; ;
Gold 195m (Au-195m) has a half-life of 30.5 sec and can be produced at the bedside from the parent mercury-195m (T 1/2 . 41.6 hr). The generator produced sterile pyrogen-free Au-195m with mercury breakthrough of 0.75 +/- 0.09 (s.e.m.) muCi per mCi of Au-195m. Approximately 20 to 25 mCi of Au-195m was produced per elution from a generator containing 155 mCi of Hg-195m. The authors compared first-pass resting Tc-99m angiograms with Au-195m angiograms in 28 patients. The correlation coefficient between the two studies was 0.92 over an ejection-fraction range from 0.22 to 0.83. In addition, they tested the reproducibility of Au-195m first-pass angiograms by performing two studies 3 min apart. In 25 patients with ejection fractions ranging from 0.20 to 0.78, the correlation coefficient between such pairs was 0.93. The nuclide is reliably and reproducibly produced, and its short half-life allows the performance of background-free sequential first-transit studies with unusually low radiation exposure to the patient.
Research Organization:
Harbor-UCLA Medical Center, Torrance, CA
OSTI ID:
5855948
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:2; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GOLD 195
GOLD ISOTOPES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MERCURY 195
MERCURY ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
SECONDS LIVING RADIOISOTOPES
VOLUME