Mechanism of prolactin action on Nb/sub 2/ node lymphoma cells
Thesis/Dissertation
·
OSTI ID:5990410
The post-receptor mechanism of action by which the pituitary hormone prolactin stimulates cell division was investigated in the Nb/sub 2/ rat lymphoma cell. The replication of Nb/sub 2/ rat lymphoma cells is specifically stimulated by prolactin in a dose dependent manner in the concentration range from 50 pg/ml to 1 ng/ml. Prolactin stimulates proteins synthesis in these cells between 0 and 2 hrs; DNA synthesis between 12 and 16 hrs, and cell replication between 16 and 24 hrs. The effect of prolactin on phospholipid metabolism was tested by measuring the rate of incorporation of (/sup 3/H) myo-inositol, (/sup 3/H) choline and (/sup 14/C) acetate over a 14 hr period. Two significant increases in phospholipid metabolism occur from 30-90 min and from 3-8 hrs. Only the increase in phosphoinositide metabolism was shown to be non-transient. The role of the phospholipase enzymes in the prolactin stimulation of mitogenesis was investigated in the Nb/sub 2/ lymphoma cells.
- Research Organization:
- Wayne State Univ., Detroit, MI (USA)
- OSTI ID:
- 5990410
- Country of Publication:
- United States
- Language:
- English
Similar Records
Phosphatidylethanolamine turnover is an early event in the response of NB sub 2 lymphoma cells to prolactin
Rat lymphoma cell bioassay for prolactin: observations on its use and comparison with radioimmunoassay
Role of phospholipids in the actions of prolactin in the mammary gland
Journal Article
·
Fri Sep 01 00:00:00 EDT 1989
· Experimental Cell Research; (United States)
·
OSTI ID:5623016
Rat lymphoma cell bioassay for prolactin: observations on its use and comparison with radioimmunoassay
Journal Article
·
Sun Dec 26 23:00:00 EST 1982
· Life Sci.; (United States)
·
OSTI ID:6303054
Role of phospholipids in the actions of prolactin in the mammary gland
Thesis/Dissertation
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:6411904
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLESTERASES
CARBOXYLIC ACID SALTS
CELL DIVISION
CHOLINE
DISEASES
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYMES
ESTERASES
ESTERS
GONADOTROPINS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INOSITOLS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPASE
LIPIDS
LIPOTROPIC FACTORS
LTH
LYMPHOMAS
MAMMALS
METABOLISM
MONOSACCHARIDES
NEOPLASMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHOSPHOLIPIDS
PITUITARY HORMONES
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLESTERASES
CARBOXYLIC ACID SALTS
CELL DIVISION
CHOLINE
DISEASES
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYMES
ESTERASES
ESTERS
GONADOTROPINS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INOSITOLS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPASE
LIPIDS
LIPOTROPIC FACTORS
LTH
LYMPHOMAS
MAMMALS
METABOLISM
MONOSACCHARIDES
NEOPLASMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HORMONES
PHOSPHOLIPIDS
PITUITARY HORMONES
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES