Mutagenicity testing of extracts from petroleum and coal tar pitches

Conference · Mon Jan 01 04:00:00 UTC 1979

OSTI ID:5983046

Rao, T K; Epler, J L; Eatherly, W P

Dimethylsulfoxide extracts of Ashland-240 petroleum pitch and Barrett M-30 coal tar pitch were tested for mutagenicity using Salmonella histidine reversion assay (Ames test). Four strains of Salmonella were employed. The strains sensitive to frameshift mutations were reverted, with the coal tar pitch indicating a three fold greater mutagenic activity than the petroleum pitch. Metabolic activation with rat liver extracts was required. As a prescreen to aid investigators in ordering their priorities, the short-term tests appear to be a valid approach to testing the large number of hazardous compounds and complex mixtures that man encounters in his environment.

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE Office of Fossil Energy (FE)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5983046
• Report Number(s): CONF-790625--6
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
010900* -- Coal
Lignite
& Peat-- Environmental Aspects
02 PETROLEUM
020900 -- Petroleum-- Environmental Aspects
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BACTERIA
BIOLOGICAL EFFECTS
COAL TAR
DATA
DATA FORMS
DMSO
ENERGY SOURCES
EXPERIMENTAL DATA
FOSSIL FUELS
FUELS
INFORMATION
ISOLATED VALUES
MICROORGANISMS
MUTAGENESIS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OTHER ORGANIC COMPOUNDS
PETROLEUM
PITCHES
SALMONELLA
SULFOXIDES
TAR
TESTING