Mechanisms of immune red cell destruction, and red cell compatibility testing
Journal Article
·
· Hum. Pathol.; (United States)
The immune destruction of red cells can occur as a complement-mediated intravascular process, or extravascularly, where the red cells are destroyed by macrophages following interaction with cell-bound IgG1, IgG3, and/or C3b. Many of the factors that affect this in vivo destruction are not taken into account during in vitro pretransfusion compatibility testing. At present, even by use of more elaborate tests, it is difficult to accurately predict the fate of a transfused unit of blood. By using some simple information, such as antibody specificity and thermal range, it is sometimes possible to predict the outcome of transfusing a unit of blood that is incompatible in vitro. At other times it may be necessary to utilize /sup 51/Cr-labeled red cells to determine the risk of transfusing such units. Because of the paucity of reported clinical correlations, macrophage/monocyte monolayer assays are of little practical value at present.
- Research Organization:
- American Red Cross Blood Services, Los Angeles, CA
- OSTI ID:
- 5977149
- Journal Information:
- Hum. Pathol.; (United States), Journal Name: Hum. Pathol.; (United States) Vol. 14:3; ISSN HPCQA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
COMPLEMENT
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
GRAFT-HOST REACTION
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MACROPHAGES
MATERIALS
NUCLEI
PHAGOCYTES
RADIOISOTOPES
SOMATIC CELLS
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANTIGEN-ANTIBODY REACTIONS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
COMPLEMENT
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
GRAFT-HOST REACTION
IMMUNE REACTIONS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MACROPHAGES
MATERIALS
NUCLEI
PHAGOCYTES
RADIOISOTOPES
SOMATIC CELLS
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS