Mechanisms of innate immunity. Cytoplasmic granules of polymorphonuclear neutrophilic granulocytes, antimicrobial action, translocation, role and fate in antimicrobial phagocytosis. Final progress report
Research includes: distribution of proteinases and cationic proteins in human polymorphonuclear granulocytes (PMN); description of specific eosinophil granules of PMN with comparison with granules of human PMN; identification of a cyanide resistant NADPH oxidase in PMN and its cosedimentation characteristics; subcellular localization of superoxide dismutase in human PMN; oxygen dependent antimicrobial activities of each granule class; distribution and appearance of specific granule enzymes in circulating leukocytes and degranulation during phagocytosis; phagocytic and intraleukocytic killing capacity of PMN deprives of their specific granules with phorbol myristate acetate, a co-carcinogen; and the PMN of an infant with Chediak Higashi syndrome, the leukocytes from two young men with chronic granulomatous disease of childhood and the PMN of many leukemic patients. Eleven papers have resulted from these studies.
- Research Organization:
- North Carolina Univ., Chapel Hill (USA). Dept. of Bacteriology and Immunology
- OSTI ID:
- 5975972
- Report Number(s):
- ORO-3628-13
- Country of Publication:
- United States
- Language:
- English
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