Mechanisms of innate immunity: cytoplasmic granules of polymorphonuclear neutrophilic granulocytes, antimicrobial action, translocation, role, and fate in antimicrobial phagocytosis. Progress report, March 1976--June 30, 1977
Progress is reported on the following research projects: characterization of the III f granules of human neutrophil polymorphonuclear granulocytes (PMN); studies on glycosidases using methylumbelliferyl derivatives of the sugars with spectrofluorometry; distribution of proteinases and cationic proteins in human PMN; comparison of granules of eosinophils with those of other PMN; identification of a cyanide-resistant NADPH oxidase in PMN; subcellular localization of superoxide dismutase in PMN; oxygen-independent antimicrobial activities of each granule class; the phagocytic and intraleukocytic killing capacity of PMN deprived of their specific granules with phorbol myristate acetate; and studies on the PMN of an infant with the Chediak Higashi syndrome. (HLW)
- Research Organization:
- North Carolina Univ., Chapel Hill (USA). Dept. of Bacteriology and Immunology
- OSTI ID:
- 7308452
- Report Number(s):
- ORO-3628-11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CHEMISTRY
CRYOGENIC FLUIDS
CYTOPLASM
ELEMENTS
ENZYMES
EOSINOPHILS
FLUIDS
GLYCOSYL HYDROLASES
HYDROLASES
IMMUNITY
LEUKOCYTES
NEUTROPHILS
NONMETALS
ORGANIC COMPOUNDS
OXIDASES
OXIDOREDUCTASES
OXYGEN
PHAGOCYTOSIS
PROTEINS