Arginine-rich cationic proteins of human eosinophil granules
Several arginine-rich cationic proteins previously isolated from granules of leukemic myeloid cells have been found to reside primarily in human eosinophil leukocytes. The major component has a molecular weight of 21,000 and it contains approximately 2.6 moles of zinc per mole of protein. Velocity centrifugation of cytoplasm from leukocytes of patients with marked eosinophilia showed that this group of proteins is packaged in the crystalloid-containing large eosinophil granules. Approximately 30% of the protein content of eosinophil granules belonged to this group of cationic proteins. Bactericidal or esterolytic activities of the cationic proteins were not detected, nor did they inhibit guinea pig anaphylatoxin or histamine-induced contraction. The basic protein previously demonstrated in guinea pig eosinophils may be analogous to the group of basic proteins of human eosinophils but great differences are found for molecular weight and amino acid composition.
- Research Organization:
- Univ. of Lund, Sweden
- OSTI ID:
- 6631940
- Journal Information:
- Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 36:5; ISSN LAINA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CENTRIFUGATION
CYTOPLASM
DISEASES
ELEMENTS
EOSINOPHILS
GUINEA PIGS
HEMIC DISEASES
LEUKEMIA
LEUKOCYTES
MAMMALS
MAN
METALS
MYELOID LEUKEMIA
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PRIMATES
PROTEINS
RODENTS
SEPARATION PROCESSES
SINGLE CELL PROTEIN
VERTEBRATES
ZINC