Histopathology of early effects of oral cadmium in the rat kidney

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454153· OSTI ID:5975296

Aughey, E; Fell, G S; Scott, R; Black, M

Adult male Wistar rats were given 50 ppm Cd in drinking water over a period of 1-24 weeks. The rats were killed and the cadmium concentration of whole blood, blood plasma, red cells, liver and kidneys estimated. The plasma metallothionein concentration was measured by radioimmunoassay. Kidney samples were taken for light, transmission and scanning electron microscopic examination. The accumulation of cadmium in the tissues was shown by a linear increase with time, after exposure for 12 weeks. Plasma Cd concentrations showed a clear increase after 3 weeks and preliminary investigation suggests that most is present as Cd-thionein. Early pathological changes in the rat kidney were seen around the 4-6 week period which coincided with the distinct rise in plasma Cd. At 12 weeks, signs of tubular necrosis, interstitial fibrosis and glomerular epithelial cell hypertrophy were present in small areas of the cortex. By 24 weeks, the renal cortex showed clear evidence of tubulo-interstitial nephritis at a Cd concentration of 60 ..mu..g Cd/g wet weight. 15 references, 12 figures.

• Research Organization: Univ. of Glasgow, Scotland
• OSTI ID: 5975296
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 54; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLASMA
BODY
BODY FLUIDS
CADMIUM
CHEMICAL ANALYSIS
DATA
DIGESTIVE SYSTEM
DISEASES
ELECTRON MICROSCOPY
ELEMENTS
ERYTHROCYTES
EXPERIMENTAL DATA
FIBROSIS
GLANDS
HYPERTROPHY
INFORMATION
ISOTOPE APPLICATIONS
KIDNEYS
LIVER
MAMMALS
MATERIALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
MICROSCOPY
NECROSIS
NEPHRITIS
NUMERICAL DATA
OPTICAL MICROSCOPY
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RATS
RODENTS
SCANNING ELECTRON MICROSCOPY
TOXICITY
TRACER TECHNIQUES
TRANSMISSION ELECTRON MICROSCOPY
UROGENITAL SYSTEM DISEASES
VERTEBRATES