Effects of low protein diet and sex difference on the amounts of metallothionein in liver and kidney of cadmium-administered rats

Journal Article · Tue Jan 01 04:00:00 EST 1985 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(85)90127-4· OSTI ID:5001330

Ninomiya, R; Inoue, Y; Koizumi, N; Tsukamoto, T

Cadmium (Cd) was orally administered in a dose of 100 ..mu..g daily a total of 100 times to investigate the effects of the intake of low (5%) protein diet and sex difference on the amounts of metallothionein (MT) in the liver and kidney. The amount of MT in the liver was significantly increased by the intake of low protein diet. In females, the increase in the amount of MT was proportional to the amount of Cd accumulated. The concentration of copper-thionein in the liver was higher in females than in males and further increased after intake of low protein diet. The levels of MT, cadmium-thionein, zinc-thionein and copper-thionein in the kidney were not influenced by the intake of low protein diet nor did show a sex difference.

• Research Organization: Hyogo College of Medicine, Japan
• OSTI ID: 5001330
• Journal Information: Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 14:11-12; ISSN CMSHA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CADMIUM COMPOUNDS
CHEMISTRY
DIET
DIGESTIVE SYSTEM
GLANDS
KIDNEYS
LIVER
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
NUTRITIONAL DEFICIENCY
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SEX DEPENDENCE
VERTEBRATES