Cysteamine depletes prolactin in young and old hyperprolactinemic rats

Journal Article · Sun May 01 04:00:00 EDT 1983 · Endocrinology; (United States)

DOI:https://doi.org/10.1210/endo-112-5-1889· OSTI ID:5974167

Simpkins, J W; Estes, K S; Millard, W J; Sagar, S M; Martin, J B

Studies were undertaken to evaluate the effects of cysteamine on serum and anterior pituitary concentrations of prolactin in hyperprolactinemic female rats. Serum prolactin was elevated in young (4 to 5 months old) rats by implantation of 17 beta-estradiol while 26- to 28-month-old rats were in constant estrus and exhibited an age-related hyperprolactinemia. At 4 h after treatment with cysteamine (90 mg/kg body wt) serum and anterior pituitary prolactin concentrations were reduced in young animals by 98 and 85%, respectively. In old constant-estrous rats, cysteamine reduced serum prolactin by 92% and anterior pituitary prolactin by 82%. In young pseudopregnant rats, cysteamine induced a prompt resumption of estrous cycles. These studies indicate that cysteamine is an effective depletor of serum and pituitary prolactin in hyperprolactinemic rats.

• Research Organization: Department of Pharmaceutical Biology, College of Pharmacy, University of Florida, Gainesville
• OSTI ID: 5974167
• Journal Information: Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 112:5; ISSN ENDOA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD SERUM
BODY
DRUGS
ENDOCRINE GLANDS
ESTROUS CYCLE
GLANDS
GONADOTROPINS
HORMONES
INHIBITION
LTH
MAMMALS
MEA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
THIOLS
VERTEBRATES