Acrylamide effects on the macaque visual system. I. Psychophysics and electrophysiology

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Invest. Ophthalmol. Visual Sci.; (United States)

OSTI ID:5963007

Merigan, W H; Barkdoll, E; Maurissen, J P.J.; Eskin, T A; Lapham, L W

Oral acrylamide produces axonal swelling and later degeneration and gliosis in the distal optic tract, especially within the lateral geniculate nucleus, of macaque monkeys. Measures of visual thresholds and cortical-evoked potentials were used to study the time course of visual changes during exposure to acrylamide in macaque monkeys. Contrast sensitivity, visual acuity, and flicker fusion frequency were reduced during exposure, and only flicker fusion recovered rapidly and completely after exposure. Pattern-reversal-evoked responses exhibited increased latency and reduced amplitude during dosing but substantially recovered after exposure. Visual acuity and contrast sensitivity for high spatial frequencies were decreased throughout the 140 days of testing after dosing. These results suggest an acute general depression of visual capacities as the initial effect of acrylamide exposure, whereas later effects were confined to high spatial frequencies. 29 references, 6 figures.

• Research Organization: Univ. of Rochester Medical Center, NY
• DOE Contract Number: AC02-76EV03490
• OSTI ID: 5963007
• Journal Information: Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 26:3; ISSN IOVSD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
AMIDES
ANIMALS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
DATA
EXPERIMENTAL DATA
EYES
FACE
HEAD
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MAMMALS
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
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SENSE ORGANS
SENSITIVITY
TOXICITY
VERTEBRATES
VISION