Acrylamide-induced visual impairment in primates
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
OSTI ID:5236802
Subchronic exposure to acrylamide monomer caused deterioration in the visual capacities of macaque monkeys. Thresholds for visual acuity and flicker-fusion were increased and the latency of pattern-evoked potentials prolonged, well before the monkeys showed overt signs of toxicity. The termination of dosing resulted in rapid recovery of flicker-fusion thresholds, gradual recovery in evoked potential latency, and only partial recovery of visual acuity.
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5236802
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 62; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
AMIDES
ANIMALS
BEHAVIOR
BODY
BODY AREAS
DOSE-RESPONSE RELATIONSHIPS
EYES
FACE
HEAD
MACACUS
MAMMALS
MONKEYS
MONOMERS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHYSIOLOGY
PRIMATES
SENSE ORGANS
SENSITIVITY
TOXICITY
VERTEBRATES
VINYL MONOMERS
VISION
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
AMIDES
ANIMALS
BEHAVIOR
BODY
BODY AREAS
DOSE-RESPONSE RELATIONSHIPS
EYES
FACE
HEAD
MACACUS
MAMMALS
MONKEYS
MONOMERS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHYSIOLOGY
PRIMATES
SENSE ORGANS
SENSITIVITY
TOXICITY
VERTEBRATES
VINYL MONOMERS
VISION