Left ventricular volumes by gated equilibrium radionuclide angiography: a new method. [/sup 99m/Tc-human serum albumin]

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.60.3.556· OSTI ID:5945299

Slutsky, R; Karliner, J; Ricci, D; Kaiser, R; Pfisterer, M; Gordon, D; Peterson, K; Ashburn, W

To compare radionuclide end-diastolic (EDV) and end-systolic (ESV) volumes with angiographic volume, we studied 52 patients with equilibrium radionuclide angiography using /sup 99m/Tc-human serum albumin within 48 h of contrast angiography. Each RR interval was divided into 20 to 28 equally timed frames and a time-activity curve generated. End-diastolic counts were taken at the early peak of the curve and end-systolic counts at its nadir. Counts were divided by the total number of processed heart beats and normalized for: 1) dose per body surface area; 2) plasma volume; and 3) counts/ml of plasma. A cardiac phantom was developed and serial volumes were studied using a normalization factor. Radionuclide values were expressed as dimensionless units and compared with either biplane angiographic volumes (in the patient studies) or known phantom volumes. Good correlations were obtained with methods 1 and 2 in 35 patients (r > 0.84), but the best correlation was obtained in 17 patients when normalization for counts/ml of plasma was used (r = 0.98; y = 0.225x - 0.121). The standard error of the estimate (SEE) was +- 11.5 ml for EDV and +- 7.3 ml for ESV. The phantom study also showed an excellent correlation (r = 0.99), with a SEE of +-6.5 ml. We conclude that a radionuclide method independent of geometric assumptions can be used to estimate left ventricular volume in man.

• Research Organization: Univ. of California Medical Center, San Diego
• OSTI ID: 5945299
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 60:3; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
CORRELATIONS
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSTIC TECHNIQUES
DRUGS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOLATED VALUES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEASURING METHODS
MEDICINE
MOCKUP
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHANTOMS
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
SCINTISCANNING
STRUCTURAL MODELS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
VOLUME
YEARS LIVING RADIOISOTOPES