Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine

Journal Article · Thu Nov 01 04:00:00 EST 1984 · Fert. Steril.; (United States)

OSTI ID:5943309

Mendizabal, A F; Quiroga, S; Farinati, Z; Lahoz, M; Nagle, C

The usefulness of the direct 4-hour radioimmunoassay of estriol-16-glucuronide (E/sub 3/G) and pregnanediol-3-glucuronide (P/sub 2/G) in first morning urine (FMU) for establishing a prognosis of the early pregnancy outcome was evaluated in 106 patients that became pregnant. Microaliquots of FMU were serially assayed from day 3 of the conception cycle until day 80 of pregnancy. The E/sub 3/G and P/sub 2/G profiles of 19 pregnancies which terminated in spontaneous abortion with either a diagnosis of the blighted ovum syndrome (n = 11) or presumption of a corpus luteum/trophoblast failure (n = 8) have been compared with those of clinically normal pregnancies (n = 87). Normal pregnancies displayed typical patterns of E/sub 3/G and P/sub 2/G development, while variations were observed in abortive events that reflected changes of the fetoplacental unit.

• Research Organization: Centro de Educacion Medica e Investigaciones Clinicas, Buenos Aires, Argentina
• OSTI ID: 5943309
• Journal Information: Fert. Steril.; (United States), Journal Name: Fert. Steril.; (United States) Vol. 42:5; ISSN FESTA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABORTION
DIAGNOSIS
ESTRANES
ESTRIOL
ESTROGENS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
ORGANIC COMPOUNDS
PATIENTS
PREGNANCY
PREGNANEDIOL
PREGNANES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
REPRODUCTIVE DISORDERS
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES