Enkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90224-Y· OSTI ID:5941716

Iadarola, M J; Ofri, D; Kleinman, J E ^[1]

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1. National Institute of Dental Research, Bethesda, MD (USA) National Institute of Mental Health, Washington, DC (USA)

Three peptide neuromodulators that are found in high concentration in the subtantia nigra: dynorphin A 1,8-met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.

• OSTI ID: 5941716
• Journal Information: Life Sciences; (USA), Vol. 48:20; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
NERVOUS SYSTEM DISEASES
PATHOGENESIS
PEPTIDES
RADIOIMMUNOASSAY
BRAIN
COMPARATIVE EVALUATIONS
ENKEPHALINS
IMMUNE REACTIONS
LIQUID COLUMN CHROMATOGRAPHY
MAN
MENTAL DISORDERS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOASSAY
BODY
CENTRAL NERVOUS SYSTEM
CHROMATOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ENDORPHINS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
POLYPEPTIDES
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SEPARATION PROCESSES
TRACER TECHNIQUES
VERTEBRATES
550901* - Pathology- Tracer Techniques