Physical properties of VNTR data, and their impact on a test of allelic independence

Journal Article · Sun Aug 01 00:00:00 EDT 1993 · American Journal of Human Genetics; (United States)

OSTI ID:5941243

Devlin, B; Risch, N ^[1]

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1. Yale Univ., New Haven, CT (United States)

In this article the authors describe the physical properties of VNTR data, as well as their effects on the two-dimensional distribution of fragment pairs. Tests of independence of alleles at a locus may confound those physical properties with allele independence. A recently proposed test by Geisser and Johnson is an example. The authors show that alleles can be strictly independent, yet the proposed test suggests large violations of allele independence because it is sensitive to well-known electrophoretic phenomena. 7 refs., 4 tabs.

• OSTI ID: 5941243
• Journal Information: American Journal of Human Genetics; (United States), Vol. 53:2; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GENOTYPE
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HUMAN POPULATIONS
RFLPS
STATISTICAL MODELS
CRIME DETECTION
DNA SEQUENCING
MATHEMATICAL MODELS
POPULATIONS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics