Independence of VNTR alleles defined as floating bins
Journal Article
·
· American Journal of Human Genetics; (United States)
OSTI ID:6974168
- North Carolina State Univ., Raleigh, NC (United States)
Data bases of VNTR fragments determined for Caucasians and blacks by Cellmark Diagnostics and Lifecodes Corporation are analyzed for independence of variants within and between loci. Floating bins are constructed around specific fragment lengths and are used to define discrete genotypes. Simple [chi][sup 2] test statistics for independence of bins within and between loci are described and applied to large sets of randomly generated four-locus profiles. The proportions of significant test statistics were about as expected under the hypothesis of independence, suggesting the absence of both Hardy-Weinberg and linkage disequilibrium. In any particular forensic application, however, these need to be performed on the fragments in question. 10 refs., 2 figs., 4 tabs.
- OSTI ID:
- 6974168
- Journal Information:
- American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:5; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
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