Testing Hardy-Weinberg equilibrium on allelic data from VNTR loci

Journal Article · Sun Nov 01 04:00:00 EST 1992 · American Journal of Human Genetics; (United States)

OSTI ID:7077002

Geisser, S ^[1]; Johnson, W ^[2]

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1. Univ. of Minnesota, Minneapolis, MN (United States)
2. Univ. of California, Davis, CA (United States)

Several methods for testing independence of pairs of alleles in a population that are obtained from a VNTR locus are presented. The authors assume an exchangeable quasi-continuous distribution of the fragment lengths used to measure the allelic pairs. Bivariate-estimated quantiles computed from the quantiles of the entire data set are then utilized for testing independence. These methods have the advantage of being minimally susceptible to the criticism of (a) the inability of a technology to measure to a few small-sized or rather large-sized fragments and (b) inadequate estimation of the homozygotic proportion. 6 refs., 3 tabs.

• OSTI ID: 7077002
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:5; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

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