Use of genetic activity profiles in hazard evaluations
Conference
·
· Trace Subst. Environ. Health; (United States)
OSTI ID:5941175
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants for purposes of hazard/risk assessment. Dose information is collected from the open literature: either the lowest effective dose (LED) or the highest ineffective dose (HID) tested is recorded for each agent and bioassay system. For each agent in the data base, the quantitative results from genetic and related test systems are represented by computer-generated bar graphs genetic activity profiles. The x-axis unit values correspond up to 200 different test systems. Bioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. The y-axis values are the logarithmically transformed LED or HID values. Genetic activity profiles were prepared for the use of the International Agency for Research on Cancer (IARC) Working Group for the preparation of IARC Monographs Supplement 6, Chemicals, Industrial Processes and Industries Associated with Cancer in Humans. These activity profiles illustrate a quantitative data base on the genetic and related effects of nearly 200 chemicals for which some date are available on carcinogenicity in humans. This information may be used for purposes of comparative chemical hazard assessment. Together with information derived from animal cancer tests and human epidemiological studies contained in IARC Monographs Supplement 7, assessments may be made regarding potential human health risks associated with exposure to chemical substances.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA)
- OSTI ID:
- 5941175
- Report Number(s):
- CONF-8805159-
- Conference Information:
- Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 12
- Country of Publication:
- United States
- Language:
- English
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