Genetic-activity profiles and hazard assessment
Technical Report
·
OSTI ID:5598715
A methodology was developed to display and evaluate multiple-test quantitative information on genetic toxicants for purposes of hazard/risk assessment. Dose information is collected from the open literature: either the lowest effective dose (LED) or the highest ineffective dose (HID) tested is recorded for each agent and bioassay system. For each agent in the data base, the quantitative results from genetic and related test systems are represented by computer-generated bar graphs genetic activity profiles. The x-axis unit values correspond to approximately 200 different test systems. Bioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. The y-axis values are the logarithmically transformed LED or HID values. Genetic activity profiles were prepared which illustrate a quantitative data base on the genetic and related effects of nearly 200 chemicals for which some data are available on carcinogenicity in humans. The information may be used for purposes of comparative chemical hazard assessment. Together with information derived from animal cancer tests and human epidemiological studies, assessments may be made regarding potential human health risks associated with exposure to chemical substances.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5598715
- Report Number(s):
- PB-89-218812/XAB; EPA--600/D-89/007
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400 -- Genetics
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
BIOLOGY
CARCINOGENS
ELEMENTS
ENVIRONMENTAL EXPOSURE
GENETICS
LEAD
MATERIALS
METALS
MUTAGENS
ORGANIC COMPOUNDS
RISK ASSESSMENT
TOXIC MATERIALS
TOXICITY
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
BIOLOGY
CARCINOGENS
ELEMENTS
ENVIRONMENTAL EXPOSURE
GENETICS
LEAD
MATERIALS
METALS
MUTAGENS
ORGANIC COMPOUNDS
RISK ASSESSMENT
TOXIC MATERIALS
TOXICITY