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Quantitative genetic-activity graphical profiles for use in chemical evaluation

Technical Report ·
OSTI ID:5320845
; ; ;
A graphic approach termed a Genetic Activity Profile (GAP) has been developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose (LED) or highest ineffective dose (HID) is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the endpoints of genetic activity. The methodology for the production and evaluation of genetic activity profiles has been developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals has been compiled by IARC and by the U.S. Environmental Protection Agency (EPA). Data are available on 299 compounds selected from volumes 1-50 of the IARC Monographs and on 115 compounds identified as Superfund Priority Substances. Structurally similar compounds frequently display qualitatively and quantitatively similar profiles of genetic activity. Through the examination of the patterns of GAPs of pairs and groups of chemicals, it is possible to make more informed decisions regarding the selection of test batteries to be used in the evaluation of chemical analogs.
Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
OSTI ID:
5320845
Report Number(s):
PB-91-219139/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOASSAY
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
GENETIC EFFECTS
STRUCTURE-ACTIVITY RELATIONSHIPS
XENOBIOTICS