The EGG 57-CO B-12 absorption test, in the evaluation of patients with low serum B-12

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5939934

Sinow, R M; Carmel, R; Siegel, M E

The Schilling Test (ST) is the standard test for diagnosing vitamin B-12 malabsorption (MA). However, patients with subtle gastric dysfunction may have normal ST, but impaired absorption of B-12 given with food. The authors have adapted an Egg B-12 Absorption Test (EBAT) in which 57-Co cyanocobalamin (57-Co B-12) is mixed with scrambled egg to evaluate this phenomenon in patients with low serum B-12, normal ST and possible subtle MA. Lyophilized egg yolk is reconstituted and mixed with 57-Co- B-12 of equal dose to that of ST. The authors studied 46 individuals: 13 controls, 5 patients with known pernicious anemia (PA), in addition to 28 patients with low serum B-12 levels and normal ST. ST/EBAT ratios were calculated. Twenty-eight test patients excreted 13.3% on ST and 3.5% on EBAT. Mean ST/EBAT ratio was 8.2 (1.4-35.9). Five had EBAT results in the PA range (<1%) and ST/EBAT ratios (14.4-35.9) that were significantly elevated. This group is also evaluated with pepsinogen I/II ratios, gastric analysis, deoxyuridine suppression tests, anti intrinsic factor, and antiparietal cell antibodies. The authors' results indicate that the EBAT can differentiate between PA and non PA patients, and that some patients with low serum B-12 levels and normal ST may, in fact, have subtle MA. The EBAT, combined with ST/EBAT ratio, may provide a means for identifying this group of patients.

• Research Organization: USC School of Medicine, Los Angeles, CA
• OSTI ID: 5939934
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
ACID PROTEINASES
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
BODY
COBALT 57
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DEOXYURIDINE
DIAGNOSIS
DIAGNOSTIC USES
DIGESTION
DIGESTIVE SYSTEM
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
GASTROINTESTINAL TRACT
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
INGESTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
LABELLING
METABOLIC DISEASES
METABOLISM
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
NUTRITIONAL DEFICIENCY
ODD-EVEN NUCLEI
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PEPSIN
PEPTIDE HYDROLASES
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
STOMACH
UPTAKE
URACILS
USES
VITAMIN B GROUP
VITAMIN B-12
VITAMINS