Skeletal muscle blood flow measured by Rb-82 during changes in plasma glucose

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5939130

Mossberg, K A; Mullani, N; Gould, K L; Taegtmeyer, H

The purpose of this work was to assess the feasibility of measuring skeletal muscle blood flow with the K+ analogue Rb-82. Flow measurements were made in the thigh muscle of anesthetized rabbits after simultaneous sortic injection of radiolabeled microspheres (15..mu..m diam) and a bolus of Rb-82. Estimates of flow as determined by Rb-82 were based on peak tissue uptake and arterial concentration achieved over 150 sc post injection and the assumption that the extraction fraction of Rb-82 in resting muscle is unity. No significant difference was found between the microsphere and Rb-82 methods. Flow estimates were an average of 18% higher with the Rb-82 method. However, the rubidium method showed less variability since the ratio of standard deviation to the mean flow ranged from .23 to .46 compared to a ratio of .47 to .56 for the microsphere method. The values for mean flow and its variability are consistent with previously published reports on blood flow measurements in the resting skeletal muscle of the anesthetized rabbit. This study suggests that valid measurements of skeletal muscle blood flow can be made using positron emitting radionuclides.

• Research Organization: Div. of Cardiology, Dept. of Medicine, Univ. of Texas Health Science Center, Houston, TX
• OSTI ID: 5939130
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD FLOW
BLOOD PLASMA
BODY FLUIDS
CARBOHYDRATES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONITORING
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
SACCHARIDES
SCINTISCANNING
TOMOGRAPHY
USES
VARIATIONS