Assessment of skeletal muscle blood flow and glucose metabolism with positron emitting radionuclides
Thesis/Dissertation
·
OSTI ID:5173534
The potassium analog, Rb-82 was used to measure skeletal muscle blood flow and the glucose analog, 18-F-2-deoxy-2-fluoro-D-glucose (FDG) was used to examine the kinetics of skeletal muscle transport and phosphorylation. New Zealand white rabbits' blood flow ranged from 1.0-70 ml/min/100g with the lowest flows occurring under baseline conditions and the highest flows were measured immediately after exercise. Elevated plasma glucose had no effect on increasing blood flow, whereas high physiologic to pharmacologic levels of insulin doubled flow as measured by the radiolabeled microspheres, but a proportionate increase was not detected by Rb-82. The data suggest that skeletal muscle blood flow can be measured using the positron emitting K+ analog Rb-82 under low flow and high flow conditions but not when insulin levels in the plasma are elevated. This may be due to the fact that insulin induces an increase in the Na+/K+-ATPase activity of the cell indirectly through a direct increase in the Na+/H+pump activity.
- Research Organization:
- Texas Univ., Houston (USA). Health Science Center
- OSTI ID:
- 5173534
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACID ANHYDRASES
ALDEHYDES
ALKALI METAL ISOTOPES
ANIMALS
ATP-ASE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BLOOD FLOW
CARBOHYDRATES
CHEMICAL REACTIONS
ELECTRON CAPTURE RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
EXERCISE
GLUCOSE
HEXOSES
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROLASES
INSULIN
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PHOSPHOHYDROLASES
PHOSPHORYLATION
RABBITS
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
SACCHARIDES
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACID ANHYDRASES
ALDEHYDES
ALKALI METAL ISOTOPES
ANIMALS
ATP-ASE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BLOOD FLOW
CARBOHYDRATES
CHEMICAL REACTIONS
ELECTRON CAPTURE RADIOISOTOPES
ENZYME ACTIVITY
ENZYMES
EXERCISE
GLUCOSE
HEXOSES
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROLASES
INSULIN
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PHOSPHOHYDROLASES
PHOSPHORYLATION
RABBITS
RADIOISOTOPES
RUBIDIUM 82
RUBIDIUM ISOTOPES
SACCHARIDES
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES