Effect of nifedipine on right ventricular ejection fraction during exercise

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5938711

Wong, D F; Selinger, S; Takeda, K; Bice, A N; Kasecamp, W; Suneja, S; Ravert, H T; Wilson, A A; Michael, J; Kennedy, T

First pass Kr-81m studies for right ventricular ejection fraction (RVEF) measurements allow multiple repeat studies within 1-2 minutes of each other, because of Kr's 13 sec half life and clearance by the lungs. In 12 normal volunteers, aged 22-35, multiple measurements of RVEF at rest, 25,50 and 100 w-s exercise, 3 and 5 min post exercise showed an average pooled RVEF of 65 +- 5, 70.2 +- 6.5, 72.7 +- 5.7, 74.5 +-7.7, 71 +- 4.4, 68.3 +- 4.0, respectively. There was good reproducibility at rest and at each exercise stage. The overall coefficient of variation was 4.17 2.55% (rest); 3.87 +- 3.03% (stress). First pass Kr-81m determination of RVEF can demonstrate changes at each stage of exercise, correlates with Tc-99m, and can be used in multiple repeat studies for determining the role of pharmacologic manipulation on RV function. In this study, despite a significant reduction in pulmonary vascular resistance with both 02 and Nifedi-pine, there was no improvement in resting or exercise RVEF.

• Research Organization: The Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 5938711
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIHYPERTENSIVE AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXERCISE
FUNCTIONS
HALF-LIFE
HEART
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLED POOL TECHNIQUES
LUNGS
METABOLISM
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PERFORMANCE
RADIOISOTOPE SCANNING
RADIOISOTOPES
RELIABILITY
RESPIRATORY SYSTEM
RETENTION FUNCTIONS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
USES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES