Validation of normal and pathologic right ventricular function using ultra-short-lived Krypton-81m

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5236539

Nienaber, C; Spielmann, R; Wasmus, B; Mathey, D; Montz, R; Bleifield, W

Measurement of right ventricular ejection fraction (RVEF) using conventional count-based, non-geometry dependent first-pass radionuclide techniques and technetium labelled compounds (T/2 = 6 hours) implies unnecessary whole body radiation and repeated injections of isotope for sequential RVEF estimate. Kr-81m (T/2 = 13 secs) continuously eluted in 5% glucose from a bed-side rubidium-81 generator is intravenously infused providing high count density and high photon flux for rapid imaging of the right-side chambers in ECG-gated equilibrium acquisition mode. A variable right anterior oblique projection is adjusted for optimal right atrio-ventricular separation. Left-sided heart and lung background is minimized by rapid decay and efficient exhalation of Kr-81m, requiring no algorithm for background correction. RV septal and free wall contours are aligned by a semiautomatic edge detection program; tricuspid and pulmonary valve planes are defined from phase images using variable ROIs to compensate for systolic valve plane motion. To cover a wide range of RVEF (13%-63%) both methods were compared in 10 normals, 11 patients (pts) with pulmonary hypertension (PH), 4 pts with RV outflow tract obstruction (RVOT-OB) and 4 pts with RV infarction (RV-MI) at rest (R) and during dynamic exercise (E). The paper concludes that equilibrium RV imaging using Kr-81m is an accurate and reproducible method with potential for serial assessment of RVEF in a variety of RV abnormalities both at R and during E. Advantages of this method include: extremely low radiation to patients, high photon flux for rapid imaging and clear atrio-ventricular separation without background.

• Research Organization: Univ. Hospital Eppendorf, Dept. of Cardiology and Nuclear-Medicine (DE)
• OSTI ID: 5236539
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXERCISE
HEART
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
OPTIMIZATION
ORGANS
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RELIABILITY
SECONDS LIVING RADIOISOTOPES
TISSUE DISTRIBUTION
UPTAKE
YEARS LIVING RADIOISOTOPES