Rest and exercise right ventricular function from gated xenon scans

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6548080

Tweddel, A C; Martin, W; McGhie, A I; McKillop, J H; Hutton, I

Right ventricular function is of considerable clinical interest in acute myocardial infarction involving the right ventricular wall and in the patient with obstructive airways disease. The aim of this study was to assess the use of Xe-133 to evaluate right ventricular ejection fraction (RVEF), as both standard first pass and gated blood pool techniques present methodological problems. 400 MBq of Xe-133 were injected intravenously over 20-25 seconds and listmode data acquired using a mobile gamma camera with an ultra high sensitivity parallel collimator. A 15/sup 0/ left anterior oblique projection was used, acquisition being initiated when right ventricular activity becomes apparent and terminated as this leaves the ventricle. With the rapid excretion of Xenon, scans can be repeated after 5 minutes. In 10 healthy volunteers, RVEF ranged from 40-55%, compared to a range 8-38% in 10 patients with acute myocardial infarction involving right ventricular wall. In 5 patients with scans repeated at 10 minutes a mean difference of 2% in RVEF was obtained. The analysis of RVEF was only subject to small inter-observer (3%), and inter-observer (2.5%) variation. In comparison with gated blood pool scintigrams good correlation of resting RVEF was obtained (r=.91, n=15). In volunteers resting RVEF increased from a mean of 43% -+ 4 to 49% -+ 7 during peak maximal supine exercise. In 10 patients with chronic obstructive airways disease, where resting RVEF was above 30%, exercise RVEF tended to increase, whereas, below 30% on peak exercise RVEF was further impaired. Gated Xenon scans offer a simple, reliable assessment of RVEF in various clinical situations with interventions.

• Research Organization: Royal Infirmary, Glasgow
• OSTI ID: 6548080
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORRELATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
EXERCISE
GAMMA CAMERAS
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED POOL TECHNIQUES
MEDICINE
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RELIABILITY
SCINTISCANNING
TRACER TECHNIQUES
XENON 133
XENON ISOTOPES