Study of absorption, excretion, metabolism, and residues in tissues in rats fed carbon-14-labeled sulfamethazine
Sprague-Dawley male and female rats received medicated feeds containing 10, 40, 160, 640, 1280, and 2560 ppm of (phenyl-U-/sup 14/C)sulfamethazine for 7 days. Urinary radioactivity accounted for 51-68% of the dose in females and 31-45% in males. Sulfamethazine and N/sup 4/-acetylsulfamethazine accounted for 76-84% of the radioactivity in females and 22-63% in males. The N/sup 4/-glucose conjugate of sulfamethazine and two other sulfamethazine conjugates, on average, accounted for 73% of the urinary metabolites in males at drug levels below 640 ppm. At drug levels above 640 ppm, the concentration of these conjugates decreased in urine to suggest that there was a saturable process(es) in the male. Females also exhibited consistently high /sup 14/C residues in tissues and blood to further indicate there were apparent sex-related differences in the metabolism of sulfamethazine in rats. Sulfamethazine and N/sup 4/-acetylsulfamethazine were identified in the liver. No strain-related differences were noted in sulfamethazine metabolism in a study with Fischer-344 male rats. 17 references, 4 figures, 6 tables.
- Research Organization:
- American Cyanamid Co., Princeton, NJ
- OSTI ID:
- 5934343
- Journal Information:
- J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 32:6; ISSN JAFCA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CLEARANCE
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
EXCRETION
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLISM
ORGANS
RATS
RODENTS
SEX DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES