Effects of sulfuric acid mist inhalation on mucous clearance and on airway fluids of rats and guinea pigs

Journal Article · Wed Jan 01 04:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530808· OSTI ID:5930852

Wolff, R K; Henderson, R F; Gray, R H; Carpenter, R L; Hahn, F F

The responses of guinea pigs and rats to inhaled sulfuric acid aerosols were compared to define species differences and to determine the small-animal model most relevant to human exposures. Rats were exposed for 6 hr to 1, 10, and 100 mg H/sub 2/SO/sub 4//m/sup 3/. Guinea pigs were exposed for 6 h to 1, 10, and 27 mg H/sub 2/SO/sub 4//m/sup 3/. Tracheal mucous clearance of guinea pigs was slowed 1 d after exposures to 1 mg H/sub 2/SO/sub 4//m/sup 3/. A tendency toward faster clearance was observed at high concentrations of H/sub 2/SO/sub 4/ for both guinea pigs and rats (statistically significant only for the rats). The speeding of mucous clearance was correlated with increases in airway sialic acid and also with the appearance of excess tracheal secretions, detected using scanning electron microscopy in both rats and guinea pigs. The responses of guinea pigs to sulfuric acid exposures were more similar to those reported for humans than were those of rats.

• Research Organization: Inhalation Toxicology Research Institute, Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5930852
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 17:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BODY FLUIDS
CLEARANCE
COLLOIDS
COMPARATIVE EVALUATIONS
DISPERSIONS
ELECTRON MICROSCOPY
GUINEA PIGS
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
MAMMALS
MATERIALS
MICROSCOPY
RATS
RODENTS
SCANNING ELECTRON MICROSCOPY
SENSITIVITY
SOLS
SULFURIC ACID
TOXICITY
VERTEBRATES