Effects in rats and guinea pigs of short-term exposures to sulfuric acid mist, ozone, and their combination

Journal Article · Sat Oct 01 04:00:00 EDT 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529584· OSTI ID:5165416

Cavender, F L ^[1]; Steinhagen, W H; Ulrich, C E; Busey, W M; Cockrell, B Y; Haseman, J K; Hogan, M D; Drew, R T

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1. Becton, Dickinson and Co. Research Center, Research Triangle Park, NC

Ozone and the oxides of sulfur are common environmental pollutants. The acute pulmonary lesions caused by ozone and sulfuric acid mist in rats and guinea pigs have been characterized. Rats are not affected by sulfuric acid mist in concentrations up to 100 mg/m/sup 3/ except for reduced body weight at the higher doses. A true alveolitis develops in guinea pigs exposed to more than 20 mg/m/sup 3/ sulfuric acid mist. The ozone lesion is primarily confined to the terminal bronchioles and proximal alveoli. In combination studies with up to 2 ppM ozone and up to 10 mg/m/sup 3/ sulfuric acid mist, the pulmonary lesion and lung/body weight data were essentially the same as in exposure to ozone alone, and the number of statistically significant synergistic effects in rats and guinea pigs was about what one would expect to observe by chance alone.

• OSTI ID: 5165416
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 3:3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRONCHI
COLLOIDS
DISEASES
DISPERSIONS
GUINEA PIGS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
LUNGS
MAMMALS
ORGANS
OZONE
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SOLS
SULFURIC ACID
SYNERGISM
VERTEBRATES
WEIGHT