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Toxicity of sulfuric acid mist to guinea pigs

Journal Article · · Arch. Ind. Hyg. Occup. Med.; (United States)
OSTI ID:5992441
; ;
Young (1 to 2 mo) and old (1 to 5 yr) guinea pigs were exposed to from 0 to 90 mg/m/sup 3/ sulfuric acid mist. LD/sub 50/ for old animals was 50 mg/m/sup 3/ for 8 hr; for young animals it was 18 mg/m/sup 3/. Zero mortality threshold was at 20 mg/m/sup 3/ for old and 8 mg/m/sup 3/ for young. Difference with age was significant. Pathology included gross and microscopic hemorrhage, edema, congestion of tract and vessels, and leukocytes and RBC in alveolar spaces. Animals that survived had spotty congestion and hemorrhage, thickening of alveolar walls, subsiding inflammation. Young guinea pigs were exposed for up to 72 hr. Dose--time mortality curves show very little change with time for concentrations of 8, 12, or 16 mg/m/sup 3/. Higher concentrations show rapid change with time. There was the same type of damage; repair was slow. Respiratory difficulty was dependent mainly on concentration, whereas deep-seated, slowly-recoverable changes depend on both concentration, and time of exposure. Spasm reaction makes guinea pigs so sensitive; mortality response was not affected by total exposure as it kills quickly. However, lung damage increases with time--dose exposure. Toxicity cannot be based on mortality alone.
OSTI ID:
5992441
Journal Information:
Arch. Ind. Hyg. Occup. Med.; (United States), Journal Name: Arch. Ind. Hyg. Occup. Med.; (United States) Vol. 5; ISSN AIHOA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
DEPOSITION
DISEASES
DISPERSIONS
GUINEA PIGS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
LUNGS
MAMMALS
MORTALITY
ORGANS
PARTICLE SIZE
PARTICLES
PATHOLOGICAL CHANGES
PATHOLOGY
RESPIRATION
RESPIRATORY SYSTEM
RETENTION
RODENTS
SIZE
SOLS
SULFURIC ACID
TOXICITY
VERTEBRATES